Gene

brd4

ID

ZDB-GENE-030131-267

Name

bromodomain containing 4

Symbol

brd4 Nomenclature History

Previous Names

fb18g03
wu:fb18g03 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Enables chromatin binding activity and histone binding activity. Acts upstream of or within thrombocyte differentiation. Located in condensed chromosome and nucleus. Is expressed in several structures, including blastoderm; blastodisc; notochord; post-vent region; and tail bud. Human ortholog(s) of this gene implicated in colon cancer and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Toyama et al., 2008

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Bielczyk-Maczyńska et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With brd4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Cornelia de Lange syndrome 6	Alliance	Cornelia de Lange syndrome 6	620568

Associated With brd4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018359	Bromodomain, conserved site
Domain	IPR001487	Bromodomain
Domain	IPR027353	NET domain
Domain	IPR031354	Bromodomain protein 4, C-terminal
Domain	IPR043508	Brdt, bromodomain, repeat I
Domain	IPR043509	Brdt, bromodomain, repeat II
Family	IPR050935	Bromodomain-containing chromatin reader
Homologous_superfamily	IPR036427	Bromodomain-like superfamily
Homologous_superfamily	IPR038336	NET domain superfamily