Gene

vapb

ID

ZDB-GENE-030131-2348

Name

VAMP (vesicle-associated membrane protein)-associated protein B and C

Symbol

vapb Nomenclature History

Previous Names

fc05d09
wu:fa96d05
wu:fc05d09
zgc:66045 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have FFAT motif binding activity. Involved in swimming behavior. Predicted to localize to endoplasmic reticulum membrane and plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Is expressed in atrium; cardiac ventricle; and heart. Orthologous to human VAPB (VAMP associated protein B and C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vapb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
amyotrophic lateral sclerosis type 8	Alliance	Amyotrophic lateral sclerosis 8	608627
autosomal dominant adult-onset proximal spinal muscular atrophy	Alliance	Spinal muscular atrophy, late-onset, Finkel type	182980

Associated With vapb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000535	Major sperm protein (MSP) domain
Family	IPR016763	Vesicle-associated membrane-protein-associated protein
Homologous_superfamily	IPR008962	PapD-like superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold