Gene
vapb
- ID
- ZDB-GENE-030131-2348
- Name
- VAMP (vesicle-associated membrane protein)-associated protein B and C
- Symbol
- vapb Nomenclature History
- Previous Names
-
- fc05d09
- wu:fa96d05
- wu:fc05d09
- zgc:66045 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have FFAT motif binding activity. Involved in regulation of heart contraction and swimming behavior. Predicted to localize to endoplasmic reticulum membrane and plasma membrane. Is expressed in atrium; cardiac ventricle; and heart. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPB (VAMP associated protein B and C).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
amyotrophic lateral sclerosis type 8 | Alliance | Amyotrophic lateral sclerosis 8 | 608627 |
autosomal dominant adult-onset proximal spinal muscular atrophy | Alliance | Spinal muscular atrophy, late-onset, Finkel type | 182980 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Immunoglobulin-like fold | Major sperm protein (MSP) domain | PapD-like superfamily | Vesicle-associated membrane-protein-associated protein |
---|---|---|---|---|---|
UniProtKB:A0A8M9PZG9
|
242 | ||||
UniProtKB:Q6P2B0
|
243 |
Interactions and Pathways
No data available
Plasmids
No data available