Gene
lars1b
- ID
- ZDB-GENE-030114-7
- Name
- leucyl-tRNA synthetase 1b
- Symbol
- lars1b Nomenclature History
- Previous Names
-
- lars
- larsb
- cb667 (1)
- wu:fb36b12
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation. Is expressed in several structures, including alar plate midbrain region; brain; digestive system; mesoderm; and musculature system. Orthologous to human LARS1 (leucyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb667 (30 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| infantile liver failure syndrome 1 | Alliance | ?Infantile liver failure syndrome 1 | 615438 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| infantile liver failure syndrome 1 | lars1bcq68/cq68 | standard conditions | Wang et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR002300 | Aminoacyl-tRNA synthetase, class Ia |
| Domain | IPR013155 | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding |
| Family | IPR004493 | Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic |
| Homologous_superfamily | IPR009008 | Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain |
| Homologous_superfamily | IPR009080 | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class Ia | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding | Aminoacyl-tRNA synthetase, class I, conserved site | Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding | Rossmann-like alpha/beta/alpha sandwich fold | Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7T837
|
1176 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lars1b-201
(1)
|
Ensembl | 5,362 nt | ||
| mRNA |
larsb-202
(1)
|
Ensembl | 2,973 nt |
Interactions and Pathways
No data available
Plasmids
No data available