Gene
thbs4b
- ID
- ZDB-GENE-020708-4
- Name
- thrombospondin 4b
- Symbol
- thbs4b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and growth factor activity. Acts upstream of or within tendon development. Predicted to be located in extracellular space and sarcoplasmic reticulum. Predicted to be active in collagen-containing extracellular matrix. Is expressed in cranial cartilage; musculature system; notochord; pectoral fin; and trunk. Orthologous to human THBS4 (thrombospondin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:111910 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Subramanian et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR008859 | Thrombospondin, C-terminal |
| Domain | IPR024665 | Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain |
| Domain | IPR048287 | Thrombospondin-like, N-terminal domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR028974 | TSP type-3 repeat |
| Homologous_superfamily | IPR046970 | Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain superfamily |
| Repeat | IPR003367 | Thrombospondin, type 3-like repeat |
| Repeat | IPR017897 | Thrombospondin, type 3 repeat |
Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | NOTCH1 EGF-like calcium-binding domain | Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain | Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain superfamily | Thrombospondin, C-terminal | Thrombospondin-like, N-terminal domain | Thrombospondin, type 3-like repeat | Thrombospondin, type 3 repeat | TSP type-3 repeat |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8JGW0
|
949 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
thbs4b-201
(1)
|
Ensembl | 3,397 nt | ||
| ncRNA |
thbs4b-002
(1)
|
Ensembl | 822 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab3-thbs4b | polyclonal | IgG | Rabbit |
|
GeneTex
|
5 | |
| Ab1-thbs4b | polyclonal | Rabbit |
|
4 |
Plasmids
No data available