Gene

ptk2ab

ID

ZDB-GENE-020114-1

Name

protein tyrosine kinase 2ab

Symbol

ptk2ab Nomenclature History

Previous Names

fak1a (1)
faka (1)
ptk2.1
ptk2 (1)
fak (1)
focal adhesion kinase (1)
wu:fa18c04

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in regulation of convergent extension involved in gastrulation. Acts upstream of or within with a positive effect on midbrain-hindbrain boundary morphogenesis. Acts upstream of or within lens fiber cell morphogenesis and regulation of protein localization. Predicted to be located in cell projection; cytoskeleton; and focal adhesion. Is expressed in eye; notochord; segmental plate; somite; and vertical myoseptum. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptk2ab Human Ortholog

No data available

Associated With ptk2ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000299	FERM domain
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR005189	Focal adhesion kinase, targeting (FAT) domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR041390	Focal adhesion kinase, N-terminal
Domain	IPR041784	FAK1/PYK2, FERM domain C-lobe
Domain	IPR049385	FAK1-like, FERM domain C-lobe
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain
Homologous_superfamily	IPR036137	Focal adhesion kinase, targeting (FAT) domain superfamily

Domain Details Per Protein

Protein	Length	Band 4.1 domain	FAK1-like, FERM domain C-lobe	FAK1/PYK2, FERM domain C-lobe	FERM/acyl-CoA-binding protein superfamily	FERM central domain	FERM domain	FERM superfamily, second domain	Focal adhesion kinase, N-terminal	Focal adhesion kinase, targeting (FAT) domain	Focal adhesion kinase, targeting (FAT) domain superfamily	PH-like domain superfamily	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Ubiquitin-like domain superfamily
UniProtKB:A0A8M9PM62 InterPro	1132
UniProtKB:A0A8M9PJ68 InterPro	1139
UniProtKB:A0A8M2B500 InterPro	1091
UniProtKB:A0A8M9PM54 InterPro	1139
UniProtKB:A0A8M2B527 InterPro	1097
UniProtKB:A0A2R8RR02 InterPro	1101
UniProtKB:A0A8M9PJ73 InterPro	1126
UniProtKB:Q98SN4 InterPro	1050
UniProtKB:A0A8M9NZ24 InterPro	1107
UniProtKB:A0A8M9PCW2 InterPro	1140
UniProtKB:A0A8M9PCX0 InterPro	1104
UniProtKB:A0A8M2B4I9 InterPro	1088
UniProtKB:A0A8M9P7Q1 InterPro	1142
UniProtKB:A0A8M9P7Q4 InterPro	1136
UniProtKB:A0A8M2B4H7 InterPro	1104
UniProtKB:A0A8M9P7Q9 InterPro	1104
UniProtKB:A0A8M9NZ18 InterPro	1136
UniProtKB:A0A8M9PCW5 InterPro	1133

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ptk2ab-201 (1) Ensembl	Ensembl	3,874 nt	Select Tool ZFIN BLAST
mRNA	ptk2ab-202 (1) Ensembl	Ensembl	3,299 nt	Select Tool ZFIN BLAST
mRNA	ptk2ab-203 (1) Ensembl	Ensembl	6,468 nt	Select Tool ZFIN BLAST
mRNA	ptk2ab-211 (1) Ensembl	Ensembl	5,753 nt	Select Tool ZFIN BLAST
mRNA	ptk2ab-212 (1) Ensembl	Ensembl	5,865 nt	Select Tool ZFIN BLAST
mRNA	ptk2ab-213 (1) Ensembl	Ensembl	6,036 nt	Select Tool ZFIN BLAST
mRNA	ptk2ab-214 (1) Ensembl	Ensembl	6,486 nt	Select Tool ZFIN BLAST
mRNA	ptk2ab-215 (1) Ensembl	Ensembl	5,664 nt	Select Tool ZFIN BLAST
mRNA	ptk2ab-216 (1) Ensembl	Ensembl	6,015 nt	Select Tool ZFIN BLAST
ncRNA	ptk2ab-002 (1) Ensembl	Ensembl	845 nt	Select Tool ZFIN BLAST
ncRNA	ptk2ab-003 (1) Ensembl	Ensembl	885 nt	Select Tool ZFIN BLAST
ncRNA	ptk2ab-005 (1) Ensembl	Ensembl	768 nt	Select Tool ZFIN BLAST
ncRNA	ptk2ab-006 (1) Ensembl	Ensembl	645 nt	Select Tool ZFIN BLAST
ncRNA	ptk2ab-008 (1) Ensembl	Ensembl	537 nt	Select Tool ZFIN BLAST
ncRNA	ptk2ab-009 (1) Ensembl	Ensembl	808 nt	Select Tool ZFIN BLAST
ncRNA	ptk2ab-011 (1) Ensembl	Ensembl	722 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-ptk2	polyclonal	ptk2aa ptk2ab	IgG	Rabbit	IHC	Life Technologies (Invitrogen)	10
Ab1-ptk2.1	polyclonal	ptk2ab	IgG	Rabbit	IHC	Santa Cruz Biotechnology, Inc.	5

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations