Gene

gfra1a

ID

ZDB-GENE-010226-2

Name

gdnf family receptor alpha 1a

Symbol

gfra1a Nomenclature History

Previous Names

zgc:110129
zmp:0000001075

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Exhibits MAP kinase kinase kinase activity. Involved in enteric nervous system development and protein-containing complex assembly. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in nervous system; presumptive enteric nervous system; pronephric duct; and vagal neural crest. Orthologous to human GFRA1 (GDNF family receptor alpha 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Shepherd et al., 2004
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gfra1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Renal hypodysplasia/aplasia 4	619887

Associated With gfra1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR016017	GDNF/GAS1
Family	IPR003438	Glial cell line-derived neurotrophic factor receptor
Family	IPR003503	Glial cell line-derived neurotrophic factor receptor, alpha 1
Family	IPR017372	Glial cell line-derived neurotrophic factor receptor, alpha 1/2
Homologous_superfamily	IPR037193	GDNF receptor alpha