FIGURE

Fig. 5

ID

ZDB-FIG-240423-6

Publication

Rao et al., 2024 - Myoglobin modulates the Hippo pathway to promote cardiomyocyte differentiation

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Fig. 5

Deletion of Mb inhibits YAP phosphorylation in neonatal mouse hearts (A) Western blot and relative quantification of pYAP to T-YAP ratios in embryonic (E14.5), fetal (postnatal day 3) and adult (10-week-old) mice. N = 3 mice per age. (B) Representative western blot and relative quantification of pYAP to T-YAP ratios in postnatal day 7 mouse hearts after injection of AAV9 virus encoding a scramble control or Mb targeting shRNA into postnatal day 1 mice. N = 5?7 mice per group. (C) Representative tissue sections and quantification of phospho histone 3 (H3P) staining from mice injected with control or Mb? targeted shRNA expressing AAV9. N = 6 mice per group. Arrow indicates H3P+ nuclei and green represents the GFP cardiomyocytes infected with AAV9. Scale bar: 50 ?m. Data are mean � SEM. ?p < 0.05, ??p < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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