Elovl4b KO larvae show a diminished visual-motor response. A: Activity plot of zebrafish larvae response to light stimulus in alternating light-dark cycles. Homozygous and heterozygous Elovl4b KO fish show reduced activity in response to light-dark cycles compared with WT controls. B: Activity plot of control experiments showing no significant difference in larval response to different sound frequencies. Shaded region = dark. Data plotted as mean ± SEM, N = 32. AU, arbitrary unit; D2L, dark to light transition; Het, heterozygous Elovl4b KO mutant; Homo, homozygous Elovl4b KO mutant zebrafish larvae; L2D, light to dark transition.
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