FIGURE

Fig. 6

ID

ZDB-FIG-240212-32

Publication

Kim et al., 2024 - Impairments of cerebellar structure and function in a zebrafish KO of neuropsychiatric risk gene znf536

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Fig. 6

Defects in cerebellar structure and function in znf536 KO zebrafish.

A, B”’ Reduced neuronal activity in KO zebrafish monitored by c-fos expression after novel tank assay, especially in the cerebellum (arrowheads). n = 3 for WT and n = 3 for KO. C Expression of Purkinje cell markers (aldoca, pvalb7, ca8) were specifically affected in the Va region. n = 3 for WT and n = 3 for KO for each marker. D Confocal images of myelinated bundles in Tg[mbp:mgfp]::znf536 KO brain, focused in the Va region. A unique circular structure (asterisk) was identified within the Va. n = 2 for WT and n = 2 for KO. CCe corpus cerebelli, Dm medial zone of the dorsal telencephalic area, TeO optic tectum, Va valvular cerebelli. Scale bars: 500 µm.

Expression Data

Genes:	aldoca ca8 EGFP fosab pvalb7
Fish:	WT znf536^{ck109a/ck109a} ck1Tg znf536^{ck109a/ck109a}; ck1Tg
Anatomical Terms:	cerebellum telencephalon valvula cerebelli valvula cerebelli myelin sheath
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	znf536^{ck109a/ck109a} znf536^{ck109a/ck109a}; ck1Tg
Observed In:	cerebellum Purkinje cell layer valvula cerebelli Purkinje cell telencephalon valvula cerebelli valvula cerebelli myelin sheath
Stage:	Adult

Phenotype Detail

Acknowledgments

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