FIGURE

Fig. 7

ID

ZDB-FIG-231215-132

Publication

Wu et al., 2021 - Genetic and epigenetic orchestration of Gfi1aa-Lsd1-cebpα in zebrafish neutrophil development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Adult gfi1aasmu10 mutants display hematological disorders. (A) The neutrophil progenitor portion is increased in 10-month-old adult gfi1aasmu10 mutants. Sorted neutrophil lineage cells from the KM of 10-month-old Tg(mpx:GFP);WT and Tg(mpx:GFP);gfi1aasmu10 mutants were subjected to May-Grünwald-Giemsa staining and separated into N1, N2 and N3 groups according to their morphology. *P<0.05 (Mann–Whitney test, n=7). Data are mean±s.e.m. (B) The neutrophil progenitor proportion is increased, whereas the well-differentiated neutrophil portion is decreased in 14-month-old adult gfi1aasmu10 mutants. *P<0.05, **P<0.01 (Mann–Whitney test, n=3). Data are mean±s.e.m. (C,D) Blood cell counts of KM (C; *P<0.05, Student's t-test, n=8) and PB (D, n=9) in 10-month-old fish were determined manually according to their morphology. Data are mean±s.e.m. (E,F) Blood cell counts of KM (E; *P<0.05, Student's t-test, n=10) and PB (E; *P<0.05, **P<0.01, ***P<0.001, Student's t-test and Mann–Whitney test, n=9) in 18-month-old fish were determined manually according to their morphology. Data are mean±s.e.m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gfi1aa^szy5/szy5; i114Tg/i114Tg
Observed In:	blood monocyte blood neutrophil head kidney common myeloid progenitor head kidney myeloid cell mature neutrophil neutrophil progenitor cell
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development