FIGURE

Fig. 6

ID

ZDB-FIG-231102-59

Publication

Sun et al., 2023 - Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Mechanisms of disorders in lipid metabolism after 72 hpe exposure of PFOA and alternatives in zebrafish. As shown in the figure, activation of PPARα by PFOA and alternatives as exogenous ligands, promoting significant changes in target genes related to lipid metabolism downstream of PPARα; Similarly, PFOA and alternatives promote the maturation of SREBP into the nucleus, causing significant changes in target genes related to lipid metabolism downstream of SREBP. Lipid metabolism catabolism, anabolism is significantly upregulated, disrupting the balance of lipid metabolism and causing lipid retention; Sterol transport related factors npc1l1, abcg1 and yjefn3 (aibp) also changed significantly, which further disturbed the lipid metabolism balance in zebrafish.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Ecotoxicol. Environ. Saf.