FIGURE

Figure 7.

ID

ZDB-FIG-231012-8

Publication

Oyarbide et al., 2023 - SBDS^R126T rescues survival of sbds^-/- zebrafish in a dose-dependent manner independently of Tp53

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Figure 7.

Tp53^M214K does not rescue neutropenia or survival in sbds mutants.

(A) Scheme of an incross of sbds^+/−; p53^M214K/M214K. (B) Sudan black staining and neutrophil count in 10 dpf larvae. (C) qRT-PCR analysis of sbds, tp53, and cdkn1a in the p53^M214K/M214K background comparing sbds KO and WT siblings. (D) Incross between WT sbds fish with 1x copy of the transgenic line in the tp53^M214K/M214K background. (E) Embryos obtained from crosses at 24 and 48 hpf. (F) qRT-PCR analysis of critical genes involved in ribosomes, metabolism, and tp53 pathways.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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