FIGURE
Fig. 2
- ID
- ZDB-FIG-230803-22
- Publication
- Owen et al., 2023 - Loss of the crumbs cell polarity complex disrupts epigenetic transcriptional control and cell cycle progression in the developing retina
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Fig. 2
Retinal organoids of a CRB1 patient. Clinical retinal imaging of a patient with CRB1-LCA8 and generation of ROs from patient-derived hiPSC. (A) Schematic of retinal differentiation 2D/3D protocol from hiPSC. (B) Fundus photograph, (C) fundus autofluorescence, and (D) retinal imaging using spectral domain-optical coherence tomography of right eye of patient with CRB1-LCA8. The nasal outer macula subfield was 414 μm thick with no signs of any oedema. Immunostaining images of WT and CRB1 RO sections at day 35 for (E) PAX6/VSX2, (F) PH3/VSX2, (G) BRN3A/VSX2, and (H) MPP5/VSX2 expression. (I) Quantification of PH3-positive cells per section analysed; * p < 0.02. Scale bars: A, 100 μm; D, 200 μm; E–H, 50 μm.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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Full text @ J. Pathol.