FIGURE

Fig. 3

ID

ZDB-FIG-230714-45

Publication

Zhang et al., 2023 - Triclocarban triggers osteoarthritis via DNMT1-mediated epigenetic modification and suppression of COL2A in cartilage tissues

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Fig. 3

Fig. 3. TCC causes metabolic dysfunction in the joint of the zebrafish anal fin. (A) Heatmap revealing the differential metabolites collected in positive ion mode; (B) Heatmap showing the differential metabolites collected in negative ion mode; (C) Principal component analysis (PCA) of the differential metabolites collected in positive ion mode; (D) Partial least squares-discriminant analysis (PLS-DA) of the differential metabolites collected in positive ion mode; (E) PCA of the differential metabolites collected in negative ion mode; (F) PLS-DA of the differential metabolites collected in negative ion mode; (G) Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment for the differential metabolites collected in positive and negative ion modes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2
Condition:	chemical treatment by environment: triclocarban
Observed In:	anal fin citrate metabolic process anal fin fatty acid biosynthetic process anal fin FHA domain binding
Stage:	Adult

Phenotype Detail

Acknowledgments

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Reprinted from Journal of hazardous materials, 447, Zhang, Y., He, L., Yang, Y., Cao, J., Su, Z., Zhang, B., Guo, H., Wang, Z., Zhang, P., Xie, J., Li, J., Ye, J., Zha, Z., Yu, H., Hong, A., Chen, X., Triclocarban triggers osteoarthritis via DNMT1-mediated epigenetic modification and suppression of COL2A in cartilage tissues, 130747130747, Copyright (2023) with permission from Elsevier. Full text @ J. Hazard. Mater.