FIGURE

FIGURE 3

ID

ZDB-FIG-230630-3

Publication

Hipke et al., 2023 - Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1

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FIGURE 3

The tardbp−/−; tardbpl−/− mutant vascular phenotype is cell autonomous. (A) Scheme of the transplantation of control Tg (fli1:EGFP)^y1 or TDP-43 KO; Tg (fli1:EGFP)^y1 donor EC cells (EC in green, injected tracer label in blue) into Tg (kdrl:HsHRAS-mCherry)^s896 hosts (EC in red). (B) The region of interest (ROI) imaged in the transplanted donor larvae is the area dorsal to the end of the yolk sack extension for all images (box). (C) Tg (fli1:EGFP)^y1 donor (EC in green, injected tracer label in blue) transplanted into Tg (kdrl:HsHRAS-mCherry)^s896 recipients (EC in red) had a wild type morphology. TDP-43 KO; Tg (fli1:EGFP)^y1 mutant donor into Tg (kdrl:HsHRAS-mCherry)^s896 recipient showed the TDP-43 deficient phenotype (n = 4). Scale bar 50 μm, anterior to the left. Displayed is the area dorsal to the end of the yolk sack extension for all images.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol