FIGURE

Fig. 6.

ID

ZDB-FIG-230609-41

Publication

Lelièvre et al., 2023 - Deficiency in hereditary hemorrhagic telangiectasia-associated Endoglin elicits hypoxia-driven heart failure in zebrafish

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Fig. 6.

Both long and short Endoglin isoforms rescue eng^−/− heart failure. (A) PCR genotyping example of established fli1a:engLong and fli1a:engshort transgenic lines. Amplicon size difference is due to exon 13 inclusion in endoglin short coding transcript. (B) Mutant phenotype frequency in clutches from, eng^+/−, Tg(fli1a:engLong) and eng^+/−, Tg(fli1a:engshort) with eng^+/− fish at 3 dpf. Total number of mutants over total number of fish analyzed is indicated above bars. (C) Genotype distribution frequency and associated survival in 5-month-old fish from crosses between eng^+/− and eng^+/−, Tg(fli1a:engLong) or eng^+/−, Tg(fli1a:engshort). Left column shows even transgene distribution among the different genotypes. Fish numbers are indicated above bars. Right column shows Kaplan–Meier representation of survival according to genotype and transgenic status. −/− versus −/−, Tg(fli1a:engLong) or Tg(fli1a:engshort), ***P<0.0001 [log-rank (Mantel–Cox) test].

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eng^ump11/ump11 (AB) eng^ump11/+ (AB) eng^ump11/+; ump12Tg (AB) eng^ump11/+; ump13Tg (AB) eng^ump11/ump11; ump12Tg (AB) eng^ump11/ump11; ump13Tg (AB)
Observed In:	whole organism
Stage Range:	Days 45-89 to Adult

Phenotype Detail

Acknowledgments

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