FIGURE
Figure 2
- ID
- ZDB-FIG-230518-91
- Publication
- Ajouaou et al., 2023 - atm Mutation and Oxidative Stress Enhance the Pre-Cancerous Effects of UHRF1 Overexpression in Zebrafish Livers
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Figure 2
Figure 2. atm−/− mutant zebrafish generated by CRISPR-Cas9. (A) Schematic representation of the atm gene from exon 1 to exon 4. Wild type and atm−/− genomic sequences and predicted amino acid sequence of atm mutant alleles are shown. The sgRNA used to generate the mutant is shown in yellow, and the PAM sequence is in red. (B) Sanger sequencing and alignment of cDNA obtained from 2–5 dpf WT and atm−/− mutants confirms the 5 bp deletion at the mRNA level. In red the deleted sequence. (C) Alignment between the predicted amino acid sequence of WT and atm mutant alleles. The amino acids predicted to be generated by atm−/− mutants are indicated by the red line.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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