FIGURE

Fig. 4

ID

ZDB-FIG-230508-67

Publication

Yu et al., 2022 - Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis

Other Figures

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Fig. 4

Fig. 4. Functional homogeneity of astrocytes in ZnCl₂-low and ZnCl₂-high groups after zinc exposure. Homogeneity of enriched biological processes in astrocytes of ZnCl₂-low cluster 4 and ZnCl₂-high cluster 3 (defense responses and immune responses, A). Venn diagrams of DEGs in both astrocyte clusters (B); Volcano plot of DEGs that overlap between the two astrocyte clusters (C) (top DEGs associated with immune functions are labeled); enriched functional processes of the overlapping DEGs in both astrocytes clusters (D); a proposed mechanism in response to zinc toxicity in astrocytes (E). GO:0006952, defense response; GO:0009611, response to wounding; GO:0042060, wound healing; GO:0050900, leukocyte migration; GO:0030593, neutrophil chemotaxis. The screening criteria of enrichment analyses were Padj < 0.05 with enrichment genes ≥ 3 or p value < 0.05 with enrichment genes ≥ 5. Otherwise, the p value is shown in the figure.

Expression Data

Genes:	cd74a cd74b il1b mhc2dab nfkbiaa
Fish:	AB
Condition:	chemical treatment by environment: zinc dichloride
Anatomical Term:	brain astrocyte
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	chemical treatment by environment: zinc dichloride
Observed In:	astrocyte apoptotic process astrocyte immune response astrocyte nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway astrocyte protein processing brain astrocyte brain leukocyte migration brain neutrophil chemotaxis
Stage:	Adult

Phenotype Detail

Acknowledgments

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