FIGURE

Figure 2

ID

ZDB-FIG-230217-149

Publication

Barazzuol et al., 2023 - Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer's Disease Pathogenesis

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Figure 2

Effect of Psen2 absence on Notch signaling and psen1 expression at early developmental stages. (a,b) Representative images and relative fluorescence quantification of psen2^+/− incross progeny in Tg(EPV.Tpi–Mmu.Hbb: EGFP)^ia12 transgenic background, both at (a) 3- and (b) 6-dpf. Genotyping was performed after image acquisition. Values represent the mean ± SEM. Data were generated from 3 independent experiments. R.I. = Relative Intensity. Scale bar: 500 µm. Statistical significance was determined by one-way ANOVA test. (c,d) Quantification of relative psen1 mRNA level in both (c) 3- and (d) 6-dpf psen2^+/+ and psen2^−/− larvae. Values represent the mean ± SEM. Data were generated from 3 biological replicates for each condition. Statistical significance was determined by two-tailed Student’s t-test.

Expression Data

Genes:	EGFP psen1
Fish:	WT psen2^ia52/ia52 ia12Tg psen2^ia52/+; ia12Tg psen2^ia52/ia52; ia12Tg
Anatomical Terms:	central nervous system whole organism
Stage Range:	Protruding-mouth to Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	psen2^ia52/+; ia12Tg psen2^ia52/ia52; ia12Tg
Observed In:	central nervous system Notch signaling pathway
Stage Range:	Protruding-mouth to Day 6

Phenotype Detail

Acknowledgments

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