FIGURE

Figure 1

ID

ZDB-FIG-230124-36

Publication

Ma et al., 2023 - Esculetin Alleviates Nonalcoholic Fatty Liver Disease on High-Cholesterol-Diet-Induced Larval Zebrafish and FFA-Induced BRL-3A Hepatocyte

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Figure 1

Lipid lowering effect of ESC on an HCD-induced larval zebrafish model. (A) The chemical structure of ESC. (B) Experimental outline of the larval zebrafish experiments. (C) Survival rate of Tablelarval zebrafish. (D) Nile red stain of larval zebrafish. (E) Oli red stain of larval zebrafish. (F) Triglyceride of larval zebrafish. (G) Total cholesterol of larval zebrafish. (H) HE stain of larval zebrafish liver, and the hepatic steatosis is pointed by red arrows. Bar indicates means ± SD. ** p < 0.01, *** p < 0.001 represent compared with the control; n.s. represents no significance; # p < 0.05, ## p < 0.01, ### p < 0.001 represents compared with the model. p < 0.05 was considered as statistically significant calculated by One-way ANOVA followed by Tukey’s test (n = 3, n indicates the replicates of the experiment).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	high cholesterol chemical treatment by environment: esculetin, high cholesterol
Observed In:	gut lipid liver whole organism cholesterol whole organism triglyceride
Stage:	Days 21-29

Phenotype Detail

Acknowledgments

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