FIGURE

Figure 3

ID

ZDB-FIG-230110-99

Publication

Gabellini et al., 2022 - CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish

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Figure 3

setd5 haploinsufficiency causes a growth delay in adult mutant zebrafish. (a) Representative images of 10-month-old setd5+/+ and setd5+/− zebrafish adults. Scale bar 500 μm. (b) Body length and body weight analysis in setd5+/+ and setd5+/− 10 months-old zebrafish adults. n = number of adults analyzed. (c) Representative images of adult brains from 10-month-old setd5+/+ zebrafish adults, evidencing the different measurements conduced for the morphometrical analysis included in (d). W, width; L, length. (d) Relative Telencephalon (Tel) length and width, Optic tectum (TeO) length and width, Cerebellum (Ce) length and width, Diencephalon (Die) length and width in adult brain, normalized to the entire brain length, from 10-month-old setd5+/+ zebrafish adults. Absolute values are included in Figure S5. (d) n = number of adult brains analyzed. Data are expressed as mean ± SEM. Statistical analysis was performed by Student’s t-test. * p < 0.05; ** p < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.