FIGURE

Fig 2

ID

ZDB-FIG-221230-20

Publication

Chen et al., 2022 - Loss of growth differentiation factor 9 causes an arrest of early folliculogenesis in zebrafish-A novel insight into its action mechanism

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Fig 2

Gonadal development from sex differentiation to maturity in gdf9 mutant.

(A) Temporal development of the ovary and testis in the control (gdf9+/-) and mutant (gdf9-/-) from gonadal differentiation (35 dpf) to puberty onset (45 dpf) and sex maturity (80 dpf). The mutant females started to differ from the control at 45 dpf when the first cohort of PV follicles with cortical alveoli emerged in the control ovary, marking the onset of puberty. No PV follicles were observed in the mutant ovary, and the follicles remained arrested at PG stage during the entire examination period. At 80 dpf, the mutant females were undergoing sex reversal to males with remnant follicles and infiltrating stromal and testicular tissues (asterisk). The testis and spermatogenesis were normal in the mutant males compared to the control. The number in each photo indicates the number of fish examined with the same phenotype. (B) Very few gdf9 mutant females could cross the PG-PV transition and their follicles showed rudiment cortical alveoli (arrowhead). PG, primary growth; PV, pre-vitellogenic; EV, early vitellogenic; FG, full-grown; SC, spermatocytes; SZ, spermatozoa.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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