FIGURE

Fig. 6

ID

ZDB-FIG-221220-30

Publication

Wang et al., 2022 - Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway

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Fig. 6

Loss of Wfs1b provokes the ER stress response. a qPCR analyses of up-regulated downstream genes of the UPR pathway. hspa5, P < 0.0001; hsp90b1, P = 0.0046; atf6, P < 0.0001; atf4b, P < 0.0001. Assessed by unpaired t test. b Diagram of the electron microscope’s operation. c–h Representative TEM imaging showed the ER morphology in wildtype (upper), wfs1b^−/− mutant (middle) and wfs1b^± mutant (bottom) larvae brain, indicating that the ER morphology was ruptured. (C′-H′) were the ER ultrastructure under magnification from the white boxes in c–f. Scale bar, 500 nm. L, rough endoplasmic reticulum; N, cell nuclei; M, mitochondria. i Statistical diagram of perimeter and Feret’ diameter among the wildtype, the wfs1b^−/− and wfs1b^+/- mutant zebrafish larvae. Assessed by ordinary one-way ANOVA

Expression Data

Genes:	atf4a atf6 hsp90b1 hspa5
Fish:	WT wfs1b^ah828/ah828
Anatomical Term:	whole organism
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	wfs1b^ah828/ah828 wfs1b^ah828/+
Observed In:	brain endoplasmic reticulum whole organism
Stage:	Day 6

Phenotype Detail

Acknowledgments

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