FIGURE

FIGURE 9

ID

ZDB-FIG-221214-50

Publication

Liu et al., 2022 - Loxhd1b inhibits the hair cell development in zebrafish: Possible relation to the BDNF/TrkB/ERK pathway

Other Figures

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FIGURE 9

Loss of function of Loxhd1b causing the defects of otic vesicle and otoliths. (A) Imaging analysis of otic vesicle and cristae hair cells in control, Loxhd1b morphants, and rescue group at 96 hpf. The yellow dotted line marks the boundary of the otic vesicle. Scale bar = 50 μm. (B) BDNF mRNA is effective to rescue the reduced number of otoliths and smaller size of otic vesicle caused by Loxhd1b MO. Scale bar = 50 μm. (C) Statistical analysis of otic vesicle area in different groups at 96 hpf. (D) Proportions of embryos with developmental defects at 72 dpf. *P < 0.05 and ***P < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-loxhd1b
Knockdown Reagent:	MO1-loxhd1b
Observed In:	otic vesicle
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.