FIGURE

Figure 2

ID

ZDB-FIG-221118-101

Publication

Seo et al., 2022 - Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS

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Figure 2

The loss of tamalin function causes neuronal cell death in the spinal cord of postembryonic zebrafish up to adulthood. (a–f) The representative images are transverse sections of the spinal cord of wildtype (a–c) and tamalin KO zebrafish (d–f) labeled with anti-Hu antibody (green) and TUNEL staining (red). (d’–f’) High magnification images of the boxed area in (d–f) show TUNEL+ Hu+ dying neurons. The dorsal side is displayed at the top. (g–i) Quantification of the number of TUNEL+ Hu+ cells in the wildtype or tamalin KO zebrafish at 1 mpf, 2 mpf, and 4 mpf (*** p = 0.0007 **** p < 0.0001, n = 10 sections from five zebrafish). Scale bars: (a–f), 20 µm. KO, knockout; mpf; months post fertilization; and TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tamalin^km12/+ (AB)
Observed In:	neuron apoptotic process spinal cord apoptotic process spinal cord neuron
Stage Range:	Days 30-44 to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.