FIGURE

FIGURE 6

ID

ZDB-FIG-221116-18

Publication

Livne et al., 2022 - Generation and characterization of a novel gne Knockout Model in Zebrafish

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FIGURE 6

gne KO larvae present disorganized slow and fast muscle fibers at 8 dpf. (A) Confocal imaging of F-actin stained gne KO muscle at 8 dpf. gne KO larvae show an abnormal Phalloidin staining pattern relative to the WT control at 8 dpf. Scale bar = 100 µm. (B) Confocal imaging of whole-mount immunostained larvae at 8 dpf by gne genotype. Zebrafish gne KO larvae exhibit impaired organization of the slow muscle fibers, stained with F59 antibody. Scale bar = 50 µm. (C) Confocal imaging of whole-mount immunostained larvae at 8 dpf by gne genotype. gne KO larvae exhibit a wavy pattern of the fast muscle fibers, and correct localization of Actin, Actinin, and Myomesin. Scale bar = 50 µm.

Expression Data

Antibodies:	Ab-F59 Ab1-actn
Fish:	gne^rm4/rm4
Anatomical Terms:	trunk musculature fast muscle cell trunk musculature slow muscle cell
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gne^rm4/rm4
Observed In:	trunk musculature fast muscle cell trunk musculature slow muscle cell
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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