FIGURE

Figure 1

ID

ZDB-FIG-221031-186

Publication

English et al., 2022 - Next-Generation SINE Compound KPT-8602 Ameliorates Dystrophic Pathology in Zebrafish and Mouse Models of DMD

Other Figures

All Figure Page

Back to All Figure Page

Figure 1

KPT−8602 improves dystrophic muscle pathology in zebrafish larvae. (A) Zebrafish drug dosing timeline; (B) Representative images of brightfield and birefringence for both unaffected (WT) and affected (sapje) zebrafish larvae. Scale bars represent 500 μm; (C) Graph summarizing the birefringence score (in percentage of affected/unaffected over total number of larvae assessed in the clutch) across untreated, vehicle-treated, KPT−8602-treated and aminophylline-treated (positive control) fish. KPT−8602 and aminophylline treatment significantly reduced the number of affected fish compared to untreated and vehicle-treated fish (data is represented as mean ± SEM, n = 60 per cohort, across 3 independent trials of n = 20 each; * p < 0.05; one-way ANOVA with Tukey’s HSD test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dmd^{ta222a/ta222a} (AB)
Observed In:	skeletal muscle
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biomedicines