FIGURE

Figure 6

ID

ZDB-FIG-220921-77

Publication

Khrystoforova et al., 2022 - Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation

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Figure 6

lrp5^-/- scales display a larger demineralized area and TRAP positive area. (A) von Kossa staining of lrp5^-/- scales revealed significantly more demineralized area (t-test, n of scales per group=120-130) than of control siblings scales. (B) TRAP staining of lrp5^-/- scales indicates significantly larger TRAP area compared to lrp5^+/+ (t-test, n of scales=95-101). Scale bar=100µm. (C) Branching of lepidotrichia in lrp5^+/+ fins occurs in distal segments (red arrows), meanwhile lrp5^-/- fish display bifurcation in proximal segments of lepidotrichia (C, red arrows). The number of normally branched fin rays is significantly lower in lrp5^-/- compared to lrp5^+/+ siblings. (D) Schematic representation of excessive branching in lrp5^-/-. Results in A, B and C are expressed as mean SD.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lrp5^{biu102/biu102} (AB)
Observed In:	lepidotrichium proximal side scale bone mineralization scale osteoclast
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)