FIGURE

Fig 3

ID

ZDB-FIG-220904-24

Publication

Wang et al., 2022 - Reduced sister chromatid cohesion acts as a tumor penetrance modifier

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Fig 3

Reduced SCC in esco2 and sgol1 haploinsufficient animals correlates with accelerated tumor onset.

(A) Representative images of “paired” and “railroad” (RR) metaphase spreads. Inset shows zoomed-in view of each phenotype. (B) The percentage of metaphase spreads in esco2^+/+ and esco2^2865/+ showing paired or RR phenotypes. Two pools of embryos were used for esco2^+/+ and esco2^2865/+ spreads from two independent experiments. A total of 92 esco2^+/+ and 119 esco2^2865/+ spreads were tallied. (C) The percentage of spreads in sgo1^+/+ and sgo1^+/- showing paired or RR phenotypes. Three pools of embryos were used for sgo1^+/+ and sgo1^m/+ spreads. A total of 131 sgo1^+/+ and 142 sgo1^+/- spreads were tallied. ** p-value < 0.01 and *** p-value < 0.001 by paired t-test. (D) Kaplan-Meier curves for tumor-free survival for p53^+/+, sgo1^+/-; p53^+/+, p53^+/- and sgo1^+/-; p53^+/- cohorts. Cohorts were established by natural single-pair breeding of sgo1^+/- X p53^+2/+ parents (all cohorts were n = 96). P-value = <0.0001 when comparing p53^+/- with sgo1^+/-; p53^+/- curves based on Log-rank (Mantel-Cox) test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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