Fig. 1

Bacterial loads and metabolic profiles of lepb⁺ and lepb^ibl54 zebrafish larvae in the absence and presence of M. marinum infection. A Representative overlap images of bright field and fluorescent images of 5 dpf entire zebrafish larvae (left panel) and the tail part of the larvae (right panel) from the lepb⁺ and lepb^ibl54 group in the absence and presence of infection. B Quantifications of bacterial pixels of the entire larvae in four groups. **p < 0.01, ****p < 0.0001. C PLS-DA analysis of metabolic profiles of pooled zebrafish larvae measured by HR-MAS NMR spectroscopy from the four groups. PLS-DA partial least square discriminant analysis. D The representative HR-MAS NMR spectra of pooled zebrafish larvae from the fours groups. Acet acetate, Ala alanine, Arg arginine, Asp aspartate, Chol cholesterol, Cit citrulline, Cys cysteine, Eta ethanolamine, FA fatty acid, Glc glucose, Gln glutamine, Glu glutamate, Gly glycine, His histidine, Ile isoleucine, Lac lactate, Leu leucine, Lys lysine, Met methionine, Phe phenylalanine, Pu putrescine, Ser serine, Tau taurine, Thr threonine, tCr total creatine (creatine + phosphocreatine), Trp tryptophan, Tyr tyrosine, NMR nuclear magnetic resonance