FIGURE

Fig. 7

ID

ZDB-FIG-220805-27

Publication

Zhang et al., 2022 - Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration

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Fig. 7

Figure 7. Proliferation of BP-PCs regulated by Tel2 is partially mediated via Hhex (A) Experimental schematic illustrating the stages of Mtz and HS treatment and analysis at BT, R0h, R24h, and R48h. (B and C) Single optical section images showing Tomato (red), PCNA (green), and DAPI (gray) expression at BT, R0h, R24h, and R48h in the WT (B) and lvl (C). (D) Single optical section images showing Tomato (red), PCNA (green), Hhex-GFP (blue), and DAPI (gray) expression at BT, R0h, R24h, and R48h in lvl with HS treatment. (E) Quantification of the percentage of PCNA+ among Tp1+ cells from BT to R48h. The proliferation rate of PCNA+ cells was decreased from R0h and fell to the minimal level at R24h in lvl, whereas the reduction was ameliorated by Hhex overexpression. n = 7–8 larvae. Values represent means ± SD. ∗∗∗p < 0.001 by t test. Scale bars, 100 μm (B–D). See also Figure S7.

Expression Data

Antibody:	Ab2-pcna
Fish:	telo2^cq122/cq122; cq109nTg/cq109nTg; cq127Tg/cq127Tg; cq1Tg/cq1Tg
Conditions:	chemical treatment by environment: metronidazole chemical treatment by environment: metronidazole, heat shock
Anatomical Term:	regenerating tissue hepatocyte
Stage Range:	Day 5 to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	telo2^cq122/cq122; cq109nTg/cq109nTg; cq127Tg/cq127Tg; cq1Tg/cq1Tg
Conditions:	chemical treatment by environment: metronidazole chemical treatment by environment: metronidazole, heat shock
Observed In:	regenerating tissue hepatocyte regenerating tissue hepatocyte proliferation
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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