FIGURE

Figure 1

ID

ZDB-FIG-220801-135

Publication

Hawkey-Noble et al., 2022 - Mutation of foxl1 Results in Reduced Cartilage Markers in a Zebrafish Model of Otosclerosis

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Figure 1

Reduction in cartilage in foxl1 mutants. (A) Alcian blue (staining cartilage) of WT and foxl1^-/- (6 dpf n = 24, 10 dpf n = 20) embryos, indicating a delay in ceratohyal cartilages at 6 dpf (green arrowhead), but a recovery begins by 10 dpf. Alizarin red indicates a delay in the ossification of the hyomandibula (red arrowhead and inserts) in foxl1 mutants at 6 dpf, which also begins to normalize by 10 dpf. (B) Longitudinal sections through jaw, demonstrating a reduced presence of cartilage formation in the upper and lower jaw as indicated by the red arrows at 6 dpf, along with a shortened and round jaw structure that progresses by 10 dpf (red circle). PQ, palatoquadrate; M, Meckel; HY, hyomandibula (hyosympletic); CH, ceratohyal; CB, ceratobranchials (yellow arrowhead); OP, operculum. Zoomed-in inserts in each panel focus on the cartilage and primary centres of ossification of the hyomandibula. Scale bars are 200 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	foxl1^nfl1/nfl1 (AB)
Observed In:	ceratobranchial cartilage ceratohyal cartilage ceratohyal cartilage ossification hyomandibula ossification hyosymplectic cartilage mandibular arch skeleton opercular flap ossification palatoquadrate arch cartilage element ventral mandibular arch cartilage element
Stage Range:	Day 6 to Days 7-13

Phenotype Detail

Acknowledgments

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