FIGURE

Fig. 1

ID

ZDB-FIG-220629-6

Publication

Ding et al., 2022 - An F0-based genetic assay in adult zebrafish for discovering modifier genes of an inherited cardiomyopathy

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Fig. 1

Genetic testing identified GBT411/dnajb6 as a deleterious modifier for bag3 cardiomyopathy. (A,B) Levels of ejection fraction (EF) and fractional shortening (FS) (in %) of bag3^e2/e2;sorbs2b^−/−, bag3^e2/e2;ano5a^−/− and bag3^e2/e2;rxraa^−/− double-mutant fish compared to bag3^e2/e2 single-mutant and WT control fish at 6 months; n=6-15, one-way ANOVA. (C) Survival (in %) of bag3^e2/e2;GB411^−/− double-mutant fish compared to single-mutant and WT control fish; n=15-24, log-rank test. (D) FS of bag3^e2/e2;dnajb6b^−/− double-mutant fish compared to single-mutant and WT control fish at 6 days dpf; n=6-7, one-way ANOVA. (E,F) Images of ventricular chamber outlines (E) and quantification of its size (F) of bag3^e2/e2;GB411^−/− double-mutant hearts at systolic stage compared to single mutants and WT controls, n=6. One-way ANOVA. Scale bar: 100 µm. *P<0.05. ns, not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bag3^xu083/xu083 dnajb6b^{xu0411Gt/xu0411Gt} bag3^xu083/xu083; ano5a^{mn0136Gt/mn0136Gt} bag3^xu083/xu083; dnajb6b^{xu0411Gt/xu0411Gt} bag3^xu083/xu083; rxraa^{xu0419Gt/xu0419Gt} bag3^xu083/xu083; sorbs2b^{mn0002Gt/mn0002Gt}
Observed In:	cardiac ventricle heart contraction whole organism
Stage Range:	Day 6 to Adult

Phenotype Detail

Acknowledgments

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