FIGURE

Fig. 5

ID

ZDB-FIG-220608-40

Publication

Yoon et al., 2022 - Zebrafish models of Alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eye

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Fig. 5

RNAseq transcriptome analysis identifies perturbation of ocular development pathways in alx1;alx3 mutants. Larvae derived from alx1^uw2016;alx3²¹¹³/+ parents were lysed individually at 5 dpf for RNA extraction and Illumina high-throughput sequencing. A heat map (A) of significantly dysregulated genes (FDR<0.5) in alx1^uw2016;alx3^uw2113 double mutants relative to alx^uw2016 siblings. A volcano plot (B) of statistical significance against fold-change in alx1^uw2016;alx3^uw2113 mutants relative to alx^uw2016 siblings. Vertical lines indicate −1-fold and +1-fold cut-offs and the horizontal line indicates the FDR=0.05 cut-off. (C,D) The top 20 enriched and top 20 suppressed terms in alx1^uw2016;alx3^uw2113 double mutants relative to alx^uw2016 siblings, identified by GSEA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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