FIGURE

Figure 6

ID

ZDB-FIG-220309-17

Publication

Banerjee et al., 2022 - Vision and sensorimotor defects associated with loss of Vps11 function in a zebrafish model of genetic leukoencephalopathy

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Figure 6

vps11(plt) and vps11(−/−) mutants at 7dpf show significantly reduced distance travelled in response to both low and high intensity acoustic/tap stimuli. (A–D) Line graphs representing distance travelled by larvae at 7dpf before and after an acoustic/tap stimulus (red arrow). (A) Response of vps11(plt) (green; n = 69) and sibling larvae (blue; n = 77) to a low intensity stimulus. (B) Response of vps11(plt) (green; n = 71) and sibling larvae (blue; n = 73) to a high intensity stimulus. (C) Response of vps11(−/−) (green; n = 54) and sibling larvae (blue; n = 54) to a low intensity stimulus. (D) Response of vps11(−/−) (green; n = 48) and sibling larvae (blue; n = 47) to a high intensity stimulus. *P < 0.05 **P < 0.01. Error bars indicate SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	vps11^wsu1/wsu1 (AB) vps11^wsu3/wsu3 (AB)
Condition:	vibration
Observed In:	response to auditory stimulus
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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