FIGURE

Figure 4

ID

ZDB-FIG-220104-103

Publication

Gharbi et al., 2021 - Reintroduction of DJ-1 in Müller Cells Inhibits Retinal Degeneration in the DJ-1 Deficient Retina

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Figure 4

Ultrastructural features in the retinal pigment epithelium of the DJ-1-deficient retina. Electron micrographs of the RPE area of DJ-1 knockouts (A,C). Images show both phagosomes (p) and the larger electron-dense structures (*), in addition to numerous small electron lucent vacuoles (LV) in RPE. Phagosomes and electron lucent vacuoles were surrounded by membranes (arrows), but no clear limited membrane was observed limiting the electron-dense structures. (B) Quantitation of area of phagosomes (p) and electron-dense structures (*); p < 0.01. Mann-Whitney-test, n = 12 (WT) and 15 (KO_DJ-1); p, phagosome; * electron-dense structure; LV, electron-lucent vacuole; nu, RPE nucleus.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	park7^{ub2000/ub2000}
Observed In:	retinal pigmented epithelium retinal pigmented epithelium phagocytic vesicle retinal pigmented epithelium vacuole
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxidants (Basel)