FIGURE

Figure 2

ID

ZDB-FIG-211219-31

Publication

Brun et al., 2021 - Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish

Other Figures

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Figure 2

Larval behavior. (A) Optomotor response of wild-type (WT) and cyp20a1 wh⁶¹ mutant larvae (n = 95–111, depending on tracking success). (B) The locomotor activity of cyp20a1-/- wh⁶¹ mutant larvae (n = 65) during the dark and the light phases in comparison to the WT larvae (n = 71). Increased movement is interpreted as hyperactivity. (C) Rapid startle response to the highest acoustic stimulus (43 dB) of WT (n = 138) and cyp20a1 wh⁶¹ (n = 127) larvae. (D) Habituation to the highest acoustic stimulus of WT and cyp20a1-/- wh⁶¹ mutant larvae measured as short-latency C-bend response (SLC; < 15 ms) per plate (n = 11) and depicted as mean ± 95 CI. All individual data points represent biologically independent replicates from three independent experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cyp20a1^wh60/wh60 (AB) cyp20a1^wh61/wh61 (AB)
Conditions:	lighting conditions vibration
Observed In:	optomotor response swimming behavior
Stage:	Day 6

Phenotype Detail

Acknowledgments

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