FIGURE
Figure 9
Figure 9
Our proposed model of regeneration during chronic hyperglycemia versus regeneration upon acute injury. Following acute injury, activated Müller glia divide to produce multipotent progenitors that can give rise to all neuronal cell types. Under conditions of chronic hyperglycemia, lost photoreceptors are replenished through neurod-expressing progenitors that likely arise in the INL. Unlike the classically described “rod progenitors”, these proliferative progenitors give rise to both rods and cones. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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