FIGURE

Fig. 2.

ID

ZDB-FIG-211118-84

Publication

Wang et al., 2021 - Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability

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Fig. 2.

Endothelial cell-specific STAT3 knockout mice exhibit decreased VEGF-induced permeability. (A) Images of footpads from WT and endothelial cell-specific STAT3 knockout (STAT3^ECKO) mice following tail vein injection with 1% Evans Blue dye and human recombinant VEGF-165 protein (2.5 µg/ml; left footpads) or PBS vehicle (right footpads) being injected into the root of the footpad. (B,C) Quantitation of Evans Blue leakage in Tie2-Cre negative; STAT3^flox/flox (WT) and Tie2-Cre positive; STAT3^flox/flox (STAT3^ECKO) mice. n=7 mice in WT group and n=6 mice in STAT3^ECKO group. Each mouse was injected with PBS on the right anterior and posterior footpads and VEGF on the left anterior and posterior footpads. Multiple biological replicates were performed and depicted findings are representative. Mean±s.e.m., one-way ANOVA followed by Bonferroni test. A.U., arbitrary units.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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