FIGURE

Figure 1

ID

ZDB-FIG-211029-127

Publication

Robinson et al., 2021 - A Novel Calpain Inhibitor Compound Has Protective Effects on a Zebrafish Model of Spinocerebellar Ataxia Type 3

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Figure 1

Treatment with BLD-2736 from 1 to 6 days post-fertilization improves SCA3 zebrafish swimming performance. (A) Representative trajectories displaying the distance swum during motor performance assays at 6 days post-fertilization. (B) Transgenic zebrafish expressing EGFP-fused human ataxin-3 with 84 polyglutamines swim shorter distances than zebrafish expressing EGFP-fused human ataxin-3 with 23 polyglutamines. Treatment with calpain inhibitors (BLD-2736 or calpeptin) improved the distance swum. All data are presented as mean ± SEM, n = 12–24 larvae were examined per group. * represents p < 0.05, ** represents p < 0.01, *** represents p < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mq15Tg; mq17Tg
Conditions:	chemical treatment by environment: calpain inhibitor chemical treatment by environment: Calpeptin
Observed In:	swimming behavior
Stage:	Day 6

Phenotype Detail

Acknowledgments

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