FIGURE

Fig. 2

ID

ZDB-FIG-211009-14

Publication

Jang et al., 2021 - Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish

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Fig. 2

Characterization and annotation of DMARs. a Bar plot illustrating the number of DMARs identified across pigment cell differentiation. No HyperDMARs were detected, except in melanophore vs. iridophore comparison. b Heatmap illustrating the DNA methylation levels of opening DARs identified in early NCC to late NCC transition. c Epigenetic dynamics of DEG promoters in melanophores and iridophores. d Genomic feature distribution of DMRs, DARs, and DMARs. e Expression fold-change of closest DEGs within 50 kb of epigenetically dynamic regions. f Line graphs and heatmaps representing average DNA methylation levels and ATAC peak signals respectively of epigenetically dynamic regions from late NCC to pigment cell-type comparison. g, h Gene ontology enrichment of DEGs within 50 kb of hypo-opening DMARs and upregulated DEGs in melanophore-specific (g) and iridophore-specific (h) comparison

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	j329Tg/j329Tg
Observed In:	iridophore chromatin binding iridophore methylated histone binding iridophore positive regulation of gene expression, epigenetic melanocyte chromatin binding melanocyte methylated histone binding melanocyte positive regulation of gene expression, epigenetic neural crest negative regulation of gene expression via chromosomal CpG island methylation neural crest cell chromatin binding neural crest cell methylated histone binding neural crest cell positive regulation of gene expression, epigenetic neural crest cell differentiation
Stage Range:	10-13 somites to Day 6

Phenotype Detail

Acknowledgments

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