FIGURE

Figure 6

ID

ZDB-FIG-211002-151

Publication

Li et al., 2021 - Functions of SMC2 in the Development of Zebrafish Liver

Other Figures

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Figure 6

Activation of the p53-dependent apoptotic pathway contributed to the small liver phenotype in SMC2^?/? mutants. (A) Phenotype comparison of WT, SMC2^?/? and SMC2^?/?/p53^?/? embryos under the Tg (fabp10a:dsRed;ela3l:EGFP) transgenic background at 72 hpf and 96 hpf. (B) WT embryos, SMC2^?/? and SMC2^?/?/p53^?/? embryos stained with the fabp10a probe at 96 hpf. (C) TUNEL analysis of apoptotic cells in the liver of SMC2^?/?/p53^?/? mutants compared to WT and SMC2^?/? mutants at 96 hpf under the Tg (fabp10a:dsRed;ela3l:EGFP) transgenic background. Scale bar, 50 ?m. (D) Quantitative analysis of the apoptotic cells in the liver. Fluorescence intensities of three WT embryos, three SMC2^?/? mutant embryos and three SMC2^?/?/p53^?/? embryo across the liver were determined using the ImageJ software. **, p < 0.01.

Expression Data

Genes:	DsRed fabp10a
Fish:	gz15Tg (AB) smc2^{zf3797/zf3797}; gz15Tg (AB) tp53^zdf1/zdf1; smc2^{zf3797/zf3797}; gz15Tg (AB)
Anatomical Term:	liver
Stage Range:	Protruding-mouth to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	smc2^{zf3797/zf3797}; gz15Tg (AB) tp53^zdf1/zdf1; smc2^{zf3797/zf3797}; gz15Tg (AB)
Observed In:	liver liver apoptotic process
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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