FIGURE

Figure 3

ID

ZDB-FIG-211001-7

Publication

Ali et al., 2021 - Met is required for oligodendrocyte progenitor cell migration in Danio rerio

Other Figures

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Figure 3

Met receptor inhibition decreases the number of OLCs in spinal cord. (A) Dose–response curve of the number of OLCs in the dorsal spinal cord of fish treated from 24 hpf to 3 dpf with 1% DMSO (n = 8) and 10 μM MK2461 in 1% DMSO in the following doses: 2.5 μM (n = 8), 5 μM (n = 8), 7.5 μM (n = 7), 10 μM (n = 4), and 12.5 μM (n = 8). Statistical test: one-way ANOVA with Dunnett’s Multiple Comparison Test. (B) Transverse sections of 76 hpf olig2:egfp;sox10:tagrfp larvae treated with DMSO or 10 μM MK2461 from 24 hpf to 3 dpf. Yellow open arrowheads denote sox10⁺/olig2⁺ OLCs. (C–F) Quantification of olig2⁺/sox10⁺ OLCs from 10 sequential 20 μm sections of olig2:egfp;sox10:tagrfp larvae treated with DMSO (n = 9) or MK2461 (n = 8) from 24 hpf to 3 dpf. Mean with SEM. Student’s t-test was used in C–F. Scale bar, 10 μm.

Expression Data

Genes:	EGFP TagRFP
Fish:	uva5Tg/uva5Tg; vu12Tg/vu12Tg
Condition:	chemical treatment by environment: MK-2461
Anatomical Term:	spinal cord glioblast
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	uva5Tg/uva5Tg; vu12Tg/vu12Tg vu12Tg/vu12Tg; vu234Tg/vu234Tg
Condition:	chemical treatment by environment: MK-2461
Observed In:	spinal cord glial cell migration spinal cord glioblast
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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