FIGURE

Fig 6

ID

ZDB-FIG-210817-8

Publication

Bengani et al., 2021 - Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability

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Fig 6

Functional analysis of <italic toggle='yes'>FMR1</italic><sup>CRE</sup> mice.

(A) Comparison of mGluR-dependent long-term depression (LTD) in CA3-CA1 components of the hippocampus of eight Fmr1^CRE male mice and eight wild-type male littermates indicates a significant Fmr1^CRE-associated decrease in LTD. (B) All quantitative data are presented as mean ±SE and p value of 0.05 or less is considered statistically significant.(C) No significant difference was observed in audiogenic seizure incidence in the hemizygous mice with the variant Fmr1^CRE(1/21) compared to wild-type littermates(3/9). Statistical significance is determined using two-tailed Fisher’s exact test and p value of 0.05 or less is considered statistically significant.(D) Significant increase in bulk protein synthesis levels in slices from dorsal hippocampus of Fmr1^CRE knock-in mutant male mice as compared to wild-type male littermates. Quantitative data is derived from number of biological replicates used (n = 6) in the experiments. Levels of significance were determined by 2-tailed Student’s t-test, with p values lower than 0.05 considered statistically significant. (* means difference is statistically significant).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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