Figure 7

Characterization of chm^ru848 zebrafish treated daily with 0.3 nM simvastatin or 700 nM fenofibrate from 24 hours after fertilization. (A) Survival days of chm^ru848 fish untreated (red) or treated with simvastatin (black) or fenofibrate (gray) (n = 4, 50 fish per group). (B) Average levels of cholesterol (μM per μg of protein) in WT fish (blue circles), and chm^ru848 zebrafish untreated (red squares) or treated with simvastatin (black squares) or with fenofibrate (gray squares) at 6 dpf (n ≥ 2, 5 fish per condition). Data represent mean ± SD. (C) Retinal sections and wholemount morphology of WT, untreated chm^ru848 fish, and chm^ru848 fish treated with simvastatin or fenofibrate at 6dpf. Scale bar: 100 μm. P value was determined using 1-way ANOVA. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.