FIGURE

Figure 1 supplement 4

ID

ZDB-FIG-210625-17

Publication

Gentile et al., 2021 - The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression

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Figure 1 supplement 4

<italic toggle='yes'>snai1b</italic> mutants exhibit reduced cardiac trabeculation.

(A–C’) Single-plane images and inner 3D surface rendering of trabecular cardiomyocytes (CMs) (asterisks in A) in 100 hpf snai1^-/- (C, C’) and snai1b^+/+ (A, A’) larvae. (B–D) Fewer delaminating (B) and trabecular (D) CMs are observed in snai1b^-/- larvae compared with snai1b^+/+ larvae at 78 (snai1b^+/+, n = 6; snai1b^-/-, n = 8) and 100 (snai1b^+/+, n = 6; snai1b^-/-, n = 9) hpf. Plot values represent means ± S.D.; p-values determined by Student’s t-test. Scale bars: 20 µm. V: ventricle; A: atrium; n: number of embryos.

Expression Data

Gene:	BFP
Fish:	bns193Tg snai1b^{bns351/bns351}; bns193Tg
Anatomical Term:	myocardium
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	snai1b^{bns351/bns351}; bns193Tg
Observed In:	cardiac muscle cell heart trabecula formation trabecular layer of ventricle
Stage:	Day 4

Phenotype Detail

Acknowledgments

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