FIGURE

Figure 6

ID

ZDB-FIG-210623-44

Publication

Liu et al., 2021 - In vivo calcium imaging reveals disordered interictal network dynamics in epileptic stxbp1b zebrafish

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Figure 6

Gap junction blockers reduce neuronal cascade intensity

(A) Representative stack summation of binary time series from stxbp1b mutants before (top row) and after (bottom row) heptanol treatment. The cumulative intensity of activation is color coded as shown in the color bar.

(B) Comparison of normalized (norm.) number (num) of cascade, maximum (max) cascade size, and maximum cascade duration (dur) before and after heptanol treatment. Data were normalized to the average value from recordings before drug treatment. (C and D) Results from propofol experiments on stxbp1b mutants. Scale bars, 100 μm. n = 5 fish for each drug test. Statistical significance is indicated as ∗p < 0.05, ∗∗p < 0.01; Student's t test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2; stxbp1b^s3001/s3001
Conditions:	chemical treatment by environment: heptan-1-ol chemical treatment by environment: propofol
Observed In:	optic tectum calcium-mediated signaling
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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