FIGURE

FIGURE 1

ID

ZDB-FIG-210428-80

Publication

Dhakal et al., 2021 - Selective Requirements for Vascular Endothelial Cells and Circulating Factors in the Regulation of Retinal Neurogenesis

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FIGURE 1

Ocular vasculature of cardiovascular disruption model systems. (A,D). Hyaloid and superficial vessels in zebrafish embryos doubly transgenic for cdh5:gal4 and UAS:nfsB-mCherry, treated with DMSO (controls; A,C), or metronidazole (Met; B,D), viewed at 48 h post-fertilization (hpf; A,B) and 72 hpf (C,D). The dorsal, nasal, and ventral radial vessels (drv, nrv, vrv, respectively) and hyaloid vasculature (hv) are visible in controls but not in Met-treated. (E,F) Hyaloid and superficial vessels of kdrl:eGFP transgenic zebrafish embryos, either normal (E) or sih–/– with no circulation and collapsed vessels (F). (G,H) Hyaloid and radial vessels of kdrl:eGFP transgenic zebrafish embryos, either normal (G) or vlt–/– with no erythrocytes but otherwise normal vasculature (H). Scale bar in A (applies to all) = 50 μm. 7-10 embryos were examined for each condition. All embryos were PTU-treated to prevent pigmentation from interfering with imaging.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol