FIGURE

Figure 6

ID

ZDB-FIG-210327-28

Publication

Brown et al., 2021 - PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons

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Figure 6

Reduced population of Otp⁺ progenitors in the TPp of pink1^-/- zebrafish at 3 months and 24 months of age. (A) Quantification of the number of Otp⁺Th1^- progenitors and the number of Otp⁺Th1⁺ DA neurons in the TPp at 3 months shows a significant reduction in the number of Otp⁺Th1^- progenitors in the pink1^-/- zebrafish compared to pink1^+/+ zebrafish (t-test, p = 0.0292, n = 2 fish for each), but no significant difference in the number of Otp⁺Th1⁺ DA neurons. (B) Quantification of the number of Otp⁺Th1^- progenitors and the number of Otp⁺Th1⁺ DA neurons in the TPp at 24 months shows a significant reduction in the number of Otp⁺Th1^- progenitors in the pink1^-/- zebrafish compared to pink1^+/+ zebrafish (t-test, p = 0.0259, n = 4 fish for each), and in the number of Otp⁺Th1⁺ DA neurons (t-test, p = 0.0453, n = 4 fish for each).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pink1^sh397/sh397
Observed In:	caudal tuberculum dopaminergic neuron caudal tuberculum neuroblast (sensu Vertebrata)
Stage:	Adult

Phenotype Detail

Acknowledgments

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