FIGURE

Fig. 5

ID

ZDB-FIG-210202-32

Publication

Reichmann et al., 2020 - The zebrafish histamine H3 receptor modulates aggression, neural activity and forebrain functional connectivity

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Fig. 5

Effects of histamine receptor H3 (hrh3) deletion on larval behaviour. A, Total distance travelled, (B) time spent immobile and (C) average velocity during beat?glide swimming of larval hrh3^?/? (KO) and corresponding wild?type (WT) fish in the larval unstimulated locomotion (UL) assay. The arrow in (C) indicates the onset of the swimming bout. n = 15/group. Mann?Whitney U test. ^?P < .01 vs WT. D, Total distance travelled, (E) time spent immobile and (F) average swim bout duration in the larval light/dark transition (L/D) assay. n = 15/group. Two?way ANOVA. Significant main effects are indicated in the graph. ^?P < .001, ^?P < .01, *P < .05. G?I, Visual startle response (VSR) test. Larval KO fish displayed (G) shorter c?bend durations, (H) shorter counter?bend durations and (I) enhanced escape swimming compared to corresponding WT fish. n = 15/group. Mann?Whitney U test. ^?P < .01, *P < .05 vs WT (J) In addition, KO fish were more likely to perform short latency c?bends (SLC) compared to long latency c?bends (LLC) and not responding at all. n = 15/group. Two?way ANOVA followed by Tukey's post?hoc test. ^?P < .001, ^?P < .01 vs SLC/KO. Data are presented as mean � SEM

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hrh3^uol1/uol1
Observed In:	startle response swimming
Stage:	Day 4

Phenotype Detail

Acknowledgments

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